FDA Approves drug to treat pain without opioid effects (nytimes.com)
49 points by remh 7 hours ago | 31 comments
121Public Access OpenVMS System (decuserve.org)
101 points by BSDobelix 3 days ago | 52 comments
122Jevons paradox (en.wikipedia.org)
191 points by wslh 2 days ago | 159 comments
123A step-by-step guide on deploying DeepSeek-R1 671B locally (snowkylin.github.io)
29 points by snowkylin 4 hours ago | 0 comments
124The ancient discovery that put a Silk Road city back on the map (bbc.com)
42 points by Thevet 2 days ago | 12 comments
125Complete hardware and software setup for running Deepseek-R1 locally (twitter.com)
242 points by olalonde 2 days ago | 191 comments
126Machine Learning in Production (CMU Course) (mlip-cmu.github.io)
495 points by azhenley 3 days ago | 36 comments
127Integration of 1,024 silicon quantum dots with on-chip electronics (phys.org)
18 points by bookofjoe 5 days ago | 0 comments
128Ice: Powerful open source menu bar manager for macOS (icemenubar.app)
30 points by Khaine 9 hours ago | 3 comments
129Show HN: I made a price aggregator to find the best PC parts deals across eBay (pcprice.watch)
19 points by tzoSkatzo a day ago | 14 comments
130Facebook ban on discussing Linux? (distrowatch.com)
851 points by rogerthis 4 days ago | 387 comments
131Interview with DeepSeek Founder: We're Done Following. It's Time to Lead (thechinaacademy.org)
120 points by oli5679 20 hours ago | 50 comments
132Discovery Coding (jimmyhmiller.github.io)
242 points by surprisetalk 2 days ago | 85 comments
133Maxima in the browser using Embedded Common Lisp on WASM (maxima-on-wasm.pages.dev)
244 points by v9v 3 days ago | 50 comments
134The impact of competition and DeepSeek on Nvidia (youtubetranscriptoptimizer.com)
650 points by eigenvalue 6 days ago | 475 comments
135Two Bites of Data Science in K (blog.zdsmith.com)
70 points by crux 5 days ago | 10 comments
136Parkinsons patient "feels cured" with new adaptive deep brain stimulation device (bbc.com)
270 points by ck2 2 days ago | 43 comments
137Supercharge SQLite with Ruby Functions (blog.julik.nl)
157 points by julik 7 days ago | 43 comments
138No Man's Sky's update introduces billions of new stars, planets, and more (blog.playstation.com)
153 points by hochmartinez 2 days ago | 122 comments
139Malimite – iOS and macOS Decompiler (github.com)
235 points by tW4r 5 days ago | 35 comments
140Using the most unhinged AVX-512 instruction to make fastest phrase search algo (gab-menezes.github.io)
229 points by cmcollier 7 days ago | 61 comments
141Going Nuts over NIST’s Standard Reference Peanut Butter (2016) (nist.gov)
113 points by rbanffy 7 days ago | 64 comments
142Prevent a Mac laptop from turning on when opening its lid or connecting to power (support.apple.com)
14 points by usaphp 7 hours ago | 2 comments
143So you wanna write Kubernetes controllers? (ahmet.im)
240 points by gokhan 8 days ago | 116 comments
144No one is disrupting banks – at least not the big ones (popularfintech.com)
230 points by kazanins 5 days ago | 427 comments
145Show HN: I made an open-source laptop from scratch (byran.ee)
3213 points by Hello9999901 8 days ago | 322 comments
146Run DeepSeek R1 Dynamic 1.58-bit (unsloth.ai)
755 points by noch 3 days ago | 329 comments
147Composable SQL (borretti.me)
264 points by earnestinger 5 days ago | 138 comments
148Desmos Animated Graphing Calculator (desmos.com)
213 points by sonicrocketman 7 days ago | 38 comments
149Hedy: Textual programming made easy (hedy.org)
226 points by 0x54MUR41 4 days ago | 92 comments
150